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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wright, I. K. Marsden, C. A. Garratt, J. C. |
| Description | Author Affiliation: Wright IK ( Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham.) |
| Abstract | Systemic administration of the 5-HT2 agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) (50 and 100 micrograms kg-1, i.v.) inhibited dorsal raphe neuronal firing. DOI (100 micrograms kg-1, i.v.) also produced a decrease in extracellular 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the frontal cortex measured by microdialysis. However, local administration of DOI into the frontal cortex produced no change in extracellular 5-HT and 5-HIAA at any dose given (1, 10 and 100ng). The results demonstrate that DOI is a potent inhibitor of 5-HT neuronal firing and terminal release and that the effects on release are not mediated by an action within the terminal region. The site of action and the receptor involved in the inhibition remains to be determined. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 2 |
| Volume Number | 99 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1990-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Amphetamines Pharmacology Cerebral Cortex Metabolism Neurons Drug Effects Raphe Nuclei Physiology Serotonin Animals Brain Chemistry Chromatography, High Pressure Liquid Dialysis Electrophysiology Hydroxyindoleacetic Acid Rats, Inbred Strains Research Support, Non-U.S. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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