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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Andersson, R. G. Håkanson, R. Grundemar, L. Grundström, N. Johansson, I. G. |
| Description | Author Affiliation: Grundemar L ( Department of Pharmacology, University of Lund, Sweden.) |
| Abstract | 1. In the present study we have examined whether neuropeptide Y (NPY) interferes with non-adrenergic, non-cholinergic nerve-mediated contractions and relaxations in the guinea-pig airways. In these experiments we have used ring preparations of bronchi and trachea, incubated in the presence of atropine, propranolol and indomethacin (each 1 microM). 2. The contractile response to electrical stimulation of non-adrenergic, non-cholinergic nerve fibres was suppressed by NPY and NPY 13-36 in a concentration-dependent manner, these agents having similar inhibitory potencies. NPY caused a more complete inhibition than the C terminal fragment. 3. NPY affected neither the basal tension nor the substance P-evoked contraction in the bronchi and trachea and did not interfere with nerve-mediated, non-adrenergic relaxation in the trachea. 4. On the basis of these results, it is suggested that NPY may act on the terminals of sensory neurones in the airways to prevent antidromic, excitatory neurotransmission by inhibiting transmitter release. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 3 |
| Volume Number | 99 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1990-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Capsaicin Pharmacology Muscle, Smooth Physiology Neurons, Afferent Drug Effects Neuropeptide Y Animals Atropine Bronchi Electric Stimulation Guinea Pigs In Vitro Techniques Indomethacin Muscle Contraction Propranolol Substance P Synaptic Transmission Tetrodotoxin Trachea Research Support, Non-U.S. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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