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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Müller-schweinitzer, E. Ellis, P. |
| Description | Author Affiliation: Ellis P ( Sandoz Pharma AG, Basel, Switzerland.) |
| Abstract | 1. Human intrapulmonary arteries have been investigated in vitro in fresh tissue or after storage at -190 degrees C in foetal calf serum containing 1.8 M dimethyl sulphoxide. 2. After cryopreservation of the arteries, maximal contractile force was reduced to 76%. This was assessed by the responses (in g) to 10 nM of the thromboxane analogue, U 46619. 3. Constricting agonists such as noradrenaline, 5-hydroxytryptamine, histamine and U 46619 stimulated fresh and frozen/thawed arteries producing pD2 values similar to the respective values determined on fresh tissues. 4. Endothelium-independent relaxant responses of U 46619-precontracted arteries to prostacyclin (PGI2), aminophylline and papaverine were generally unchanged after storage. The same was true for relaxant response to the potassium channel activator P-1075 whereas the pD2 values for SDZ PCO 400, RP 49356 and cromakalim were somewhat diminished. 5. Nevertheless, a significant correlation was obtained when the apparent pD2 values for all agonists on fresh and frozen/thawed tissues were compared (P less than 0.001). 6. The evidence suggests that after cryopreservation of human intrapulmonary arteries at -190 degrees C, mechanisms of both contraction and relaxation are well-maintained. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 2 |
| Volume Number | 103 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1991-06-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Cryopreservation Muscle, Smooth, Vascular Physiology Pulmonary Artery 15-Hydroxy-11 Alpha,9 Alpha-(epoxymethano)prosta-5,13-dienoic Acid Endothelium, Vascular Drug Effects In Vitro Techniques Muscle Contraction Muscle Relaxation Potassium Channels Prostaglandin Endoperoxides, Synthetic Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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