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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hayward, N. J. Woodruff, G. N. Harding, M. Mcknight, A. T. Lloyd, S. A. Hughes, J. |
| Description | Author Affiliation: Hayward NJ ( Parke-Davis Neuroscience Research Centre, Addenbrookes Hospital Site, Cambridge.) |
| Abstract | 1. The urethane-anaesthetized, vagotomised rat preparation was used to investigate the effects of the histamine H2-antagonist ranitidine, the proton pump inhibitor omeprazole and the CCKB/gastrin antagonists CI-988, PD 136450 and L-365,260 on pentagastrin-, histamine- and bethanechol-induced gastric acid secretion. 2. The novel CCKB/gastrin antagonists CI-988 and PD 136450, and L-365,260 dose-dependently inhibited pentagastrin-induced secretion. The ED50 value for PD 136450 was 0.05 mumol kg-1, the same following intravenous or subcutaneous administration. 3. CI-988 and PD 136450 administered subcutaneously at dose levels highly effective for antagonism of pentagastrin responses had no effect on basal acid secretion. 4. Ranitidine inhibited pentagastrin-, bethanechol-, and histamine-induced acid secretion, whereas the CCKB/gastrin antagonists inhibited only the secretory response to pentagastrin. 5. The selective CCKA antagonist, devazepide, was inactive at up to 300 mumol kg-1 i.p. against the three stimulants of acid secretion. 6. CI-988 and PD 136450 will be useful research tools with which to investigate the role of CCKB/gastrin receptors in gastric acid secretion and the trophic activities of gastrin and cholecystokinin (CCK) on the gastrointestinal tract. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 4 |
| Volume Number | 104 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1991-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Cholecystokinin Antagonists & Inhibitors Gastric Acid Secretion Gastrins Phenylurea Compounds Animals Anti-Anxiety Agents Pharmacology Atropine Benzodiazepinones Bethanechol Compounds Dose-Response Relationship, Drug Histamine Indoles Meglumine Analogs & Derivatives Omeprazole Ranitidine Rats, Inbred Strains Receptors, Cholecystokinin |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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