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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Erkelens, D. W. Kappelle, A. C. Gispen, W. H. Bravenboer, B. Van Buren, T. Traber, J. |
| Description | Author Affiliation: Kappelle AC ( Department of Medical Pharmacology, Rudolf Magnus Institute, University of Utrecht, The Netherlands.) |
| Abstract | 1. Neuropathy is a frequently diagnosed complication in diabetic patients but an effective treatment does not exist. 2. The development of neuropathy in streptozotocin-induced diabetic rats was monitored by measuring the motor and sensory nerve conduction velocity in the sciatic nerve. 3. A significant decrease in sensory and motor nerve conduction velocity was apparent in young, 14-week-old diabetic rats as compared to non-diabetic, age-matched controls 4 weeks after the induction of diabetes with streptozotocin. 4. Intraperitoneal treatment with the Ca2+ channel blocker, nimodipine, from week 4 onwards, in a dosage of 10 mg kg-1 or 20 mg kg-1 intraperitoneally per 48 h, resulted in a significant increase in sensory and motor nerve conduction velocity whereas treatment with 5 mg kg-1 intraperitoneally per 48 h was not effective. 5. One-year-old, adult, diabetic rats treated with nimodipine 20 mg kg-1 (treatment started again 4 weeks after induction of diabetes mellitus) also showed an increase of both sensory and motor nerve conduction velocity as compared to diabetic rats treated with placebo. 6. It is concluded that nimodipine ameliorates existing experimental diabetic neuropathy in streptozotocin-induced diabetic rats in both young and adult animals. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 3 |
| Volume Number | 108 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1993-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Diabetes Mellitus, Experimental Complications Diabetic Neuropathies Drug Therapy Nimodipine Therapeutic Use Aging Physiology Animals Blood Glucose Metabolism Body Weight Electrophysiology Motor Neurons Drug Effects Neural Conduction Neurons, Afferent Rats, Inbred Strains Rats, Wistar Sciatic Nerve Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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