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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ross, S. B. Kelder, D. |
| Description | Author Affiliation: Kelder D ( Department of Neuropharmacology, Södertälje, Sweden.) |
| Abstract | 1. The effect of various classes of compounds on the rapidly developed tolerance to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)-induced corticosterone secretion was examined. 2. Compounds activating the gamma-aminobutyric acidA (GABAA) receptor-chloride complex, i.e. muscimol (3 mg kg-1), diazepam (5 mg kg-1), flunitrazepam (1 mg kg-1), sodium pentobarbitone (10-30 mg kg-1) and chlormethiazole ethane disulphonate (50 mg kg-1) counteracted the development of tolerance when injected before or simultaneously with, but not 15 min after 8-OH-DPAT. 3. At these doses the compounds produced an acute increase in serum corticosterone but had, with the exception of muscimol, no effect on the response to the challenge dose of 8-OH-DPAT 24 h later. Muscimol significantly decreased the response. 4. The GABAA chloride channel antagonist, picrotoxin (1 mg kg-1, s.c.), but not bicuculline (1 mg kg-1, i.p.) potentiated the development of tolerance to 8-OH-DPAT-induced corticosterone secretion. 5. A number of compounds with widely differing pharmacological actions were examined and found to have no effect on the development of tolerance to 8-OH-DPAT-induced corticosterone secretion. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 1 |
| Volume Number | 109 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1993-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | 8-Hydroxy-2-(di-n-propylamino)tetralin Pharmacology Corticosterone Secretion Ion Channels Drug Effects Membrane Proteins Receptors, GABA-A Animals Benzodiazepines Bicuculline Chloride Channels Chlormethiazole Blood Drug Tolerance Muscimol Pentobarbital Picrotoxin Rats, Sprague-Dawley |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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