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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shigenobu, K. Ueno, Y. Nishio, S. |
| Description | Author Affiliation: Ueno Y ( Toray Industries, Inc., Basic Research Laboratories, Kamakura, Japan.) |
| Abstract | 1. The present study was performed to determine whether beraprost, a new stable analogue of prostacyclin, may exert beneficial effects on the transmembrane action potentials during normoxia and hypoxia-reoxygenation in isolated right ventricular muscles of the guinea-pig. 2. Under normal oxygenation, beraprost (0.01-100 mumol-1) had no effects on the electrophysiological parameters. 3. Hypoxic conditions induced a decrease in action potential duration (APD) without affecting other action potential parameters. Beraprost inhibited this hypoxia-induced decrease in APD. However, beraprost had no effect on the decrease in contractile force induced by hypoxia, whereas it significantly improved the recovery of contractile force after reoxygenation. 4. Pinacidil-induced shortening of APD was not antagonized by beraprost. 5. Hypoxia significantly decreased the myocardial adenosine triphosphate (ATP) level, which was also prevented by beraprost. 6. These results suggested that beraprost may inhibit the hypoxia-induced shortening of APD by some mechanisms which contribute to the maintenance of muscle ATP level. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 4 |
| Volume Number | 109 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1993-08-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Epoprostenol Analogs & Derivatives Heart Drug Effects Anoxia Physiopathology Action Potentials Adenosine Triphosphate Metabolism Animals Pharmacology Guanidines Guinea Pigs Heart Ventricles In Vitro Techniques Membrane Potentials Myocardial Contraction Myocardium Oxygen Papillary Muscles Pinacidil Vasodilator Agents |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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