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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zierhut, W. Ball, H. A. |
| Description | Author Affiliation: Zierhut W ( Preclinical Research Department, Ciba-Geigy Ltd., Basel, Switzerland.) |
| Abstract | We investigated whether in vivo inhibition of protein kinase C (PKC) can prevent the development of vascular tolerance and restore the sensitivity of isolated vessels to nitroglycerin (NTG). Tolerance was induced in male Wistar rats by a constant i.v. infusion of NTG 1 mg kg-1 h-1, a dose which did not alter blood pressure. After 72 h, the aorta was removed and the sensitivity of aortic rings to NTG tested. Chronic NTG infusion resulted in a 5.5 fold decrease in NTG-sensitivity as compared with controls (vehicle), indicating the development of vascular tolerance. The simultaneous in vivo administration of the specific PKC inhibitor N-benzoyl-staurosporine (30 mg kg-1 day-1) prevented this decrease in NTG sensitivity. These results suggest a role for PKC activation in the development of vascular NTG tolerance. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 1 |
| Volume Number | 119 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1996-09-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Nitroglycerin Pharmacology Protein Kinase C Antagonists & Inhibitors Vasodilator Agents Animals Aorta Drug Effects Blood Pressure Drug Tolerance Physiology Heart Rate In Vitro Techniques Muscle, Smooth, Vascular Phenylephrine Rats, Wistar |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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