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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Krzymowski, T. Stefanczyk-krzymowska, S. Wasowska, B. Skipor, J. Grzegorzewski, W. |
| Description | Author Affiliation: Stefanczyk-Krzymowska S ( Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Division of Reproductive Endocrinology and Pathophysiology, Olsztyn, Poland.) |
| Abstract | 1. On Day 10 of the oestrous cycle in pigs, after laparotomy noradrenaline (NA), methoxamine (alpha 1-adrenomimetic, M), Prazosin (alpha 1-adrenolytic, Pr) in total doses of 4 mumol, and saline were infused (10 min) into the superficial layer of mesovarium on both sides of the ovarian pedicle vasculature, close to the ovary. 2. Blood flow in the ovarian artery, heart rate and progesterone (P4) and androstenedione (A4) secretion from the ovary and their concentrations in the ovarian venous effluent, as well as the concentrations of P4 and A4 in the blood supplying the oviduct and the uterus, were determined. 3. A significant increase of P4 and A4 secretion after NA and M infusion and increased concentrations of P4 and A4 in the ovarian venous effluent were found, but these changes did not influence the counter current transfer of hormones from the venous effluent into arterial blood supplying the oviduct and the uterus. 4. Infusion of Pr caused a significant decrease of P4 and A4 secretion and their concentrations in the ovarian venous effluent and significantly increased A4 concentration in the blood supplying the oviduct and uterus. 5. The results indicate that stimulation of alpha 1-adrenoceptors in the area of ovarian vasculature did not influence, whereas block of alpha 1-adrenoceptors affected, the local concentration of steroid hormones in the blood supplying the oviduct and the part of the uterus proximal to the ovary, despite the changes in the concentrations of steroid hormones in the ovarian effluent. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 5 |
| Volume Number | 120 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1997-03-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Androstenedione Secretion Fallopian Tubes Blood Supply Ovary Progesterone Receptors, Adrenergic, Alpha-1 Physiology Surgical Flaps Uterus Adrenergic Alpha-Agonists Pharmacology Animals Methoxamine Norepinephrine Prazosin Drug Effects Swine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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