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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Paiva, A. C. Paiva, T. B. Feres, T. Borges, A. C. Silva, E. G. |
| Description | Author Affiliation: Feres T ( Department of Biophysics, Escola Paulista de Medicina, São Paulo, SP Brazil.) |
| Abstract | The alpha2-adrenoceptor function in mesenteric arteries of spontaneously hypertensive rats (SHR) was investigated by comparing membrane potential changes in response to adrenergic agonists in preparations from female SHR, Wistar-Kyoto (WKY) and normotensive Wistar rats (NWR). Resting membrane potential was found to be less negative in mesenteric arteries from SHR than in those from NWR and WKY. Apamin induced a decrease in the membrane potential of mesenteric artery rings without endothelium from NWR and WKY, but had no effects in those from SHR. Both UK 14,304 and adrenaline, in the presence of prazosin, induced a hyperpolarization that was significantly lower in de-endothelialized mesenteric rings from SHR than in those from NWR and WKY. In mesenteric rings with endothelium, however, similar hyperpolarization was observed in the three strains. In NWR mesenteric rings with endothelium the hyperpolarization induced by activation of alpha2-adrenoceptors was abolished by apamin, whereas in intact SHR mesenteric rings this hyperpolarization was slightly reduced by apamin and more efficiently reduced by Nomega-nitro-L-arginine. It is concluded that the activity of potassium channels coupled to alpha2-adrenoceptors is altered in the smooth muscle cells of SHR mesenteric arteries, contributing to their less negative membrane potential. On the other hand, the endothelial alpha2-receptors are functioning in mesenteric vessels from SHR and their stimulation induces a hyperpolarization mainly through the release of nitric oxide. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 6 |
| Volume Number | 125 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1998-11-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Hypertension Physiopathology Mesenteric Arteries Muscle, Smooth, Vascular Ultrastructure Receptors, Adrenergic, Alpha-2 Physiology Adrenergic Alpha-Agonists Pharmacology Adrenergic Alpha-Antagonists Animals Apamin Biological Factors Brimonidine Tartrate Endothelium, Vascular Drug Effects Enzyme Inhibitors In Vitro Techniques Membrane Potentials Nitric Oxide Nitroarginine Prazosin Quinoxalines Rats, Inbred SHR Rats, Inbred WKY Research Support, Non-U.S. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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