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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Poole, S. Ferreira, S. H. Veiga, F. H. Cunha, F. Q. Lorenzetti, B. B. |
| Description | Author Affiliation: Cunha FQ ( Department of Pharmacology, Faculty of Medicine of Ribeirão, Preto, University of São Paulo, Brazil.) |
| Abstract | 1. The effect of IL-4 on responses to intraplantar (i.pl.) carrageenin, bradykinin, TNFalpha, IL-1beta, IL-8 and PGE2 was investigated in a model of mechanical hyperalgesia in rats. Also, the cellular source of the IL-4 was investigated. 2. IL-4, 30 min before the stimulus, inhibited responses to carrageenin, bradykinin, and TNFalpha, but not responses to IL-1beta, IL-8 and PGE2. 3. IL-4, 2 h before the injection of IL-1beta, did not affect the response to IL-1beta, whereas IL-4, 12 or 12+2 h before the IL-1beta, inhibited the hyperalgesia (-30%, -74%, respectively). 4. In murine peritoneal macrophages, murine IL-4 for 2 h before stimulation with LPS, inhibited (-40%) the production of IL-1beta but not PGE2. Murine IL-4 (for 16 h before stimulation with LPS) inhibited LPS-stimulated PGE2 but not IL-1beta. 5. Anti-murine IL-4 antibodies potentiated responses to carrageenin, bradykinin and TNFalpha, but not IL-1beta and IL-8, as well as responses to bradykinin in athymic rats but not in rats depleted of mast cells with compound 40/80. 6. These data suggest that IL-4 released by mast cells limits inflammatory hyperalgesia. During the early phase of the inflammatory response the mode of action of the IL-4 appears to be inhibition of the production TNFalpha, IL-1beta and IL-8. In the later phase of the response, in addition to inhibiting the production of pro-inflammatory cytokines, IL-4 also may inhibit the release of PGs. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 1 |
| Volume Number | 126 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1999-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Cytokines Pharmacology Hyperalgesia Prevention & Control Inflammation Interleukin-4 Animals Antibodies, Monoclonal Immunology Therapeutic Use Bradykinin Carrageenan Cell Count Dextrans Dinoprostone Metabolism Drug Synergism Excipients Foot Pathology Hindlimb Chemically Induced Interleukin-1 Interleukin-8 Lipopolysaccharides Macrophages, Peritoneal Cytology Drug Effects Mast Cells Mice Rats, Nude Rats, Wistar Tumor Necrosis Factor-alpha Research Support, Non-U.S. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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