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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Thompson, G. G. Fraser, C. M. Forrest, G. Brodie, M. J. Sills, G. J. |
| Description | Author Affiliation: Fraser CM ( University Department of Medicine and Therapeutics, Western Infirmary, Glasgow.) |
| Abstract | 1. Glutamine synthetase (GS) is a key enzyme in the regulation of glutamate neurotransmission in the central nervous system. It is responsible for the conversion of glutamate to glutamine, and for the detoxification of ammonia. 2. We have investigated the effects of single and repeated intraperitoneal administration of a range of established and new anti-epileptic drugs on GS activity in mouse brain. 3. Four hours after the final dose, animals were sacrificed and the brains removed for analysis of GS activity. 4. Both single and repeated doses of phenytoin and carbamazepine were found to reduce enzyme activity (P<0.05). 5. Single doses of phenobarbitone, felbamate and topiramate were without effect, however repeated administration of these drugs dose-dependently reduced GS activity (P<0.05). 6. Single and repeated doses of sodium valproate, vigabatrin, lamotrigine, gabapentin, tiagabine, levetiracetam and desglycinyl-remacemide were found to have no effect on GS activity. 7. The reduction in enzyme activity demonstrated is unlikely to be related to the anti-epileptic actions of these drugs, but may contribute to their toxicity. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 7 |
| Volume Number | 126 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1999-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Anticonvulsants Pharmacology Brain Drug Effects Glutamate-Ammonia Ligase Ammonia Metabolism Animals Enzymology Dose-Response Relationship, Drug Mice Mice, Inbred ICR |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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