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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lafon, C. Saubusse, P. Soubrié, P. Keane, P. E. Fournier, J. Marmouget, C. Labie, C. Le Fur, G. |
| Description | Author Affiliation: Labie C ( Department of Neuropsychiatry Research, Sanofi Recherche, Toulouse, France. christophe.labie@sanofi.com) |
| Abstract | The neurotrophic factor promoting activity of the neuroprotective compound SR57746A was evaluated in primary cultures of neonatal rat cortical astrocytes by studying the synthesis of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). A concentration- and time-dependent increase of nerve growth factor mRNA was induced by SR57746A (10 nM-1 microM). In these astrocytes, BDNF mRNA contents were increased to a significant but smaller extent, and beta-actin mRNA showed no variation. SR57746A (1 microM) induced increases of both de novo protein translation after 6 h of incubation and NGF release into the extracellular medium after 6-24 h. These effects were preceded by a transient augmentation of junB, c-fos and c-jun mRNA contents. These increases of AP-1 family mRNA were associated with increased nuclear AP-1 binding activity. The results show that SR57746A can increase the synthesis and release of NGF in rat cortical astrocytes. Such effects may contribute to the drug's previously described neuroprotective effects. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 1 |
| Volume Number | 127 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 1999-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Astrocytes Metabolism Cerebral Cortex Naphthalenes Pharmacology Nerve Growth Factors Biosynthesis Neuroprotective Agents Pyridines Animals Animals, Newborn Drug Effects Brain-Derived Neurotrophic Factor Genetics Cells, Cultured Cytology Enzyme-Linked Immunosorbent Assay Precipitin Tests Protein Biosynthesis RNA, Messenger Rats, Sprague-Dawley Single-Strand Specific DNA And RNA Endonucleases Transcription Factor AP-1 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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