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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Uchida, D. Yamamoto, T. Tatsuno, I. Kurihara, T. Sakashita, Y. |
| Description | Author Affiliation: Sakashita Y ( Department of Anesthesiology, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260-8670, Japan.) |
| Abstract | The role of PACAP receptor in nociceptive transmission was investigated in vitro using maxadilan, a PACAP receptor selective agonist and max.d.4, a PACAP receptor selective antagonist. Potentials, from a ventral root (L3 - L5) of an isolated spinal cord preparation or a spinal cord - saphenous nerve - skin preparation from 0 - 3-day-old rats, were recorded extracellularly. In the isolated spinal cord preparation, single shock stimulation of a dorsal root at C-fibre strength induced a slow depolarizing response lasting about 30 s (slow ventral root potential; slow VRP) in the ipsilateral ventral root of the same segment. Bath-application of max. d.4 (0.01 - 3 microM) inhibited the slow VRP in a concentration-dependent manner. In the spinal cord - saphenous nerve - skin preparation, application of capsaicin (0.1 microM) to the skin evoked a depolarization of the ventral root. This response was also depressed by max.d.4 (1 microM). Application of maxadilan evoked a long-lasting depolarization in a concentration-dependent manner in the spinal cord preparation. In the presence of max.d.4 (0.3 microM), the concentration response curve of maxadilan was shifted to the right. Reverse transcription-polymerase chain reaction (RT - PCR) experiments demonstrated the existence of PACAP receptor and VPAC(2) receptor in the neonatal rat spinal cord and [(125)I]-PACAP27 binding was displaced almost completely by maxadilan and max.d.4, but not by vasoactive intestinal peptide (VIP). These data indicate that PACAP receptor is dominantly distributed in the neonatal rat spinal cord. The present study suggests that PACAP receptor may play an excitatory role in nociceptive transmission in the neonatal rat spinal cord. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 8 |
| Volume Number | 132 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 2001-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Animals, Newborn Metabolism Nerve Fibers Physiology Neurons, Afferent Receptors, Pituitary Hormone Spinal Cord Animals Electrophysiology Drug Effects Neuropeptides Neurotransmitter Agents Pituitary Adenylate Cyclase-Activating Polypeptide RNA, Messenger Biosynthesis Rats, Sprague-Dawley Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide Receptors, Vasoactive Intestinal Peptide Reverse Transcriptase Polymerase Chain Reaction Cytology Tetrodotoxin Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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