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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Besson, Pierre Roger, Sébastien Le Guennec, Jean-yves |
| Description | Author Affiliation: Roger S ( Nutrition, Croissance et Cancer, Emi-U 0211, Faculté de Médecine, 2 Bd Tonnellé, Tours 37032, France.) |
| Abstract | 1. A voltage-dependent sodium current has been described in the highly invasive breast cancer cell line MDA-MB-231. Its activity is associated with the invasive properties of the cells. The aim of our study was to test whether this current (I(Na)) is sensitive to three representative calcium channel blockers: verapamil, diltiazem and nifedipine. I(Na) was studied in patch-clamp conditions. 2. I(Na) was sensitive to verapamil (IC(50)=37.6+/-2.5 microM) and diltiazem (53.2+/-3.6 microM), while it was weakly sensitive to nifedipine. 3. The tetrodotoxin (TTX) concentration, which fully blocks I(Na) (30 microM), did not affect cell proliferation. Diltiazem and verapamil, at concentrations that do not fully block I(Na), strongly reduced cell proliferation, suggesting, regarding proliferation, that these molecules act on targets distinct from sodium channels. These targets are probably not other ionic channels, since the current measured at the end of a 500 ms long pulse in the voltage range between -60 and +40 mV was unaffected by verapamil and diltiazem. 4. We conclude that the sodium channel expressed in MDA-MB-231 cells is sensitive to several calcium channel blockers. The present study also underlines the danger of concluding to the possible involvement of membrane channel proteins in any phenomenon on the sole basis of pharmacology, and without an electrophysiological confirmation. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 4 |
| Volume Number | 141 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 2004-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Breast Neoplasms Metabolism Calcium Channel Blockers Pharmacology Sodium Channels Pathology Cell Division Drug Effects Cell Line, Tumor Cell Survival Diltiazem Electrophysiology Nifedipine Potassium Channel Blockers Tetraethylammonium Tetrodotoxin Verapamil |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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