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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hata, Fumiaki Kitayama, Muneyoshi Hirayama, Nobue Fujita, Akikazu Takeuchi, Tadayoshi Kushida, Masahiko |
| Spatial Coverage | Japan |
| Description | Author Affiliation: Takeuchi T ( Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Science, Osaka Prefecture University, 1-1 Gakuen-cho, Sakai Osaka 599-8531, Japan. takeuchi@vet.osakafu-u.ac.jp) |
| Abstract | 1. Mechanisms involved in Ca(2+) sensitization of contractile elements induced by the activation of muscarinic receptors in membrane-permeabilized preparations of the rat proximal and distal colon were studied. 2. In alpha-toxin-permeabilized preparations from the rat proximal and distal colon, Ca(2+) induced a rapid phasic and subsequent tonic component. After Ca(2+)-induced contraction reached a plateau, guanosine 5'-triphosphate (GTP) and carbachol (CCh) in the presence of GTP further contracted preparations of both the proximal and distal colon (Ca(2+) sensitization). Y-27632, a rho-kinase inhibitor, inhibited GTP plus CCh-induced Ca(2+) sensitization more significantly in the proximal colon than in the distal colon. 3. Y-27632 at 10 microm had no effect on Ca(2+)-induced contraction or slightly inhibited phorbol-12,13-dibutyrate-induced Ca(2+) sensitization in either proximal or distal colon. Chelerythrine, a protein kinase C inhibitor, inhibited GTP plus CCh-induced Ca(2+) sensitization in the distal colon, but not in the proximal colon. The component of Ca(2+) sensitization that persisted after the chelerythrine treatment was completely inhibited by Y-27632. 4. In beta-escin-permeabilized preparations of the proximal colon, C3 exoenzyme completely inhibited GTP plus CCh-induced Ca(2+) sensitization, but PKC(19-31) did not. In the distal colon, C3 exoenzyme abolished GTP-induced Ca(2+) sensitization. It inhibited CCh-induced sensitization by 50 % and the remaining component was inhibited by PKC(19-31). 5. These results suggest that both protein kinase C and rho pathways in parallel mediate the Ca(2+) sensitization coupled to activation of muscarinic receptors in the rat distal colon, whereas the rho pathway alone mediates this action in the proximal colon. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 4 |
| Volume Number | 142 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 2004-06-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Calcium Metabolism Carbachol Pharmacology Colon, Ascending Drug Effects Colon, Descending Myocytes, Smooth Muscle ADP Ribose Transferases Alkaloids Amides Animals Bacterial Toxins Benzophenanthridines Botulinum Toxins Antagonists & Inhibitors Cell Membrane Permeability Pathology Escin Guanosine Triphosphate Hemolysin Proteins Intracellular Signaling Peptides And Proteins Muscle Contraction Physiology Peptide Fragments Phenanthridines Phorbol 12,13-Dibutyrate Protein Kinase C Protein-Serine-Threonine Kinases Pyridines Rats, Wistar Receptors, Muscarinic Tritium Type C Phospholipases Rho-Associated Kinases Research Support, Non-U.S. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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