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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Trifilieff, Alexandre Bonneau, Olivier Wyss, Daniel |
| Description | Author Affiliation: Wyss D ( Novartis Institutes for BioMedical Research, Respiratory Diseases Area, Horsham RH12 5AB, UK.) |
| Abstract | Airway hyper-reactivity to inhaled adenosine, mediated via mast cell activation, is a cardinal feature of asthma. Animal models have been developed in several species to mimic this phenomenon, but only in the rat has a mast cell involvement been clearly defined. In this study, a model of ovalbumin-induced adenosine hyper-reactivity was developed in BALB/c mice to determine whether mast cells are involved in this phenomenon. Sensitised mice were challenged one, two or three times, on a daily basis, and airway responses to the stable adenosine analogue NECA (5'-N-ethylcarboxamido adenosine) determined 4 and 24 h after each challenge. Airway hyper-reactivity was observed in ovalbumin-challenged mice 4 h after a single challenge and to a minor extent 24 h after a single challenge and 4 h after two challenges. Cromolyn (20 mg ml(-1)), given by aerosol an hour before the NECA provocation, fully inhibited the airway hyper-reactivity observed 4 h after a single allergen challenge, suggesting a role for mast cells in this response. The airway space cellular inflammation was not affected by cromolyn. As observed in human asthma, an acute treatment with steroid (budesonide 3 mg kg(-1), given an hour before the allergen challenge) inhibited the NECA airway hyper-reactivity and significantly inhibited the airway space cellular inflammation. These data suggest that the ovalbumin-challenged BALB/c mice can be considered as a suitable model to study the adenosine-induced airway hyper-reactivity phenomenon observed in human asthma. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 7 |
| Volume Number | 145 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 2005-08-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Adenosine-5'-(N-ethylcarboxamide) Administration & Dosage Anti-Asthmatic Agents Pharmacology Asthma Immunology Cromolyn Sodium Disease Models, Animal Mast Cells Animals Bronchoalveolar Lavage Fluid Cytology Bronchoconstriction Drug Effects Bronchodilator Agents Budesonide Dose-Response Relationship, Drug Immunization Mice Mice, Inbred BALB C Ovalbumin Pneumonia Chemically Induced Respiratory Hypersensitivity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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