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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Weger, Wolfgang |
| Description | Author Affiliation: Weger W ( Department of Dermatology, Medical University of Graz, Graz, Austria. wolfgang.weger@klinikum-graz.at) |
| Abstract | Psoriasis is a chronic inflammatory disease affecting 1-3% of the general population. Among psoriatic patients, 5-40% are affected by psoriatic arthritis. Due to the chronic nature of the disease, patients suffer from substantial psychological and financial burdens, thus adding to a significantly impaired quality of life. Traditional systemic therapies for psoriasis, such as methotrexate, cyclosporin A, retinoids or PUVA therapy, have a potential for long-term toxicity and may not always provide sufficient improvement of the disease. The development of novel therapies targeting key steps in the pathogenesis of psoriasis and psoriatic arthritis now provide new and efficient treatment options. Biological therapies for the treatment of psoriasis and/or psoriatic arthritis are defined by their mode of action and can be classified into three categories: the T-cell modulating agents (alefacept and efalizumab), the inhibitors of tumour necrosis factor-alpha (TNFalpha blockers, e.g. adalimumab, certolizumab, etanercept, golimumab and infliximab) and the inhibitors of interleukin (IL) 12 and IL-23 (e.g. ustekinumab and briakinumab). This article provides a brief overview of the currently approved biological agents in the European Union and of some newer agents, such as briakinumab, certolizumab and golimumab. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 4 |
| Volume Number | 160 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 2010-06-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Anti-Inflammatory Agents, Non-Steroidal Adverse Effects Therapeutic Use Arthritis, Psoriatic Drug Therapy Biological Products Psoriasis Animals Pharmacokinetics Pharmacology Antibodies, Monoclonal Etiology Immunology Physiopathology Chronic Disease Immunoglobulin Fragments Interleukin-12 Antagonists & Inhibitors Interleukin-23 Product Surveillance, Postmarketing Recombinant Fusion Proteins T-Lymphocytes Drug Effects Physiology Tumor Necrosis Factor-alpha |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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