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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kupferschmidt, David A. Rotzinger, Susan Erb, Suzanne Lovejoy, David A. |
| Description | Author Affiliation: Kupferschmidt DA ( Centre for the Neurobiology of Stress, Department of Psychology, University of Toronto Scarborough, Toronto, Ontario, Canada.) |
| Abstract | BACKGROUND AND PURPOSE: The stress-related neuropeptide, corticotropin-releasing factor (CRF), has become an important focus of studies of cocaine addiction, and in particular, the effects of stress on cocaine-related behaviours. A recently discovered peptide system, the teneurin C-terminal associated peptides (TCAP), has been implicated in the regulation of the stress response, via a CRF-related mechanism. Here we have determined whether treatment with TCAP-1, a synthetic analogue of TCAP, modulated two cocaine-related behaviours induced by CRF: reinstatement of cocaine seeking, and expression of cocaine-induced behavioural sensitization. EXPERIMENTAL APPROACH: In Experiment 1, rats trained to self-administer cocaine were given acute or repeated (once daily for 5 days) i.c.v. injections of TCAP-1 before tests for reinstatement in response to CRF (105 pmol, i.c.v.), intermittent footshock stress (0.9 mA), or cocaine (15 mg·kgâ »¹, i.p.). In Experiment 2, rats pre-exposed to cocaine (15-30 mg·kgâ »¹, i.p.) or saline for 7 days were treated with TCAP-1 (once daily for 5 days; i.c.v.) and subsequently tested for locomotor responses to CRF (105 pmol, i.c.v.) or cocaine (15 mg·kgâ »¹, i.p.). KEY RESULTS: Five day pre-exposure with TCAP-1 blocked CRF-, but not footshock- or cocaine-induced reinstatement of cocaine seeking; acute pretreatment with TCAP-1 was without effect in all test conditions. Similarly, repeated TCAP-1 pre-exposure blocked the cocaine-sensitized locomotor response to CRF, but not to cocaine. CONCLUSIONS AND IMPLICATIONS: Repeated TCAP-1 exposure induced robust and selective inhibition of cocaine-related behavioural responses to CRF, suggesting that TCAP-1 may normalize signalling within CRF systems dysregulated by cocaine exposure. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 3 |
| Volume Number | 162 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 2011-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Cocaine Administration & Dosage Corticotropin-Releasing Hormone Pharmacology Drug-Seeking Behavior Drug Effects Nerve Tissue Proteins Animals Dopamine Uptake Inhibitors Motor Activity Rats, Long-Evans Self Administration Research Support, Non-U.S. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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