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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Businco, F. Fratta, W. Goldberg, S. R. Fattore, L. Pigliacampo, B. Scherma, M. Satta, V. Dessi, C. Fadda, P. |
| Description | Author Affiliation: Scherma M ( Department of Biomedical Science, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Monserrato (Cagliari), Italy.) |
| Abstract | BACKGROUND AND PURPOSE: Binge eating disorder (BED) is characterized by excessive food intake during short periods of time. Recent evidence suggests that alterations in the endocannabinoid signalling could be involved in the pathophysiology of BED. In this study, we investigated whether pharmacological manipulation of endocannabinoid transmission may be effective in modulating the aberrant eating behaviour present in a validated rat model of BED. EXPERIMENTAL APPROACH: Binge-type eating was induced in female rats by providing limited access to an optional source of dietary fat (margarine). Rats were divided into three groups, all with ad libitum access to chow and water: control (C), with no access to margarine; low restriction (LR), with 2 h margarine access 7 days a week; high restriction (HR), with 2 h margarine access 3 days a week. KEY RESULTS: Compared with the LR group, the HR group consumed more margarine and this was accompanied by an increase in body weight. The cannabinoid CB1/CB2 receptor agonist Δ9-tetrahydrocannabinol significantly increased margarine intake selectively in LR rats, while the fatty acid amide hydrolase inhibitor URB597 showed no effect. The CB1 receptor inverse agonist/antagonist rimonabant dose-dependently reduced margarine intake in HR rats. Notably, in HR rats, chronic treatment with a low dose of rimonabant induced a selective long-lasting reduction in margarine intake that did not develop tolerance, and a significant and persistent reduction in body weight. CONCLUSIONS AND IMPLICATIONS: Chronic pharmacological blockade of CB1 receptors reduces binge eating behaviour in female rats and may prove effective in treating BED, with an associated significant reduction in body weight. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 4 |
| Volume Number | 169 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 2013-06-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Binge-Eating Disorder Drug Therapy Cannabinoid Receptor Antagonists Therapeutic Use Disease Models, Animal Endocannabinoids Antagonists & Inhibitors Piperidines Pyrazoles Receptor, Cannabinoid, CB1 Signal Transduction Drug Effects Animals Behavior, Animal Chemically Induced Metabolism Cannabinoid Receptor Agonists Administration & Dosage Toxicity Dose-Response Relationship, Drug Dronabinol Drug Inverse Agonism Drug Tolerance Agonists Energy Intake Feeding Behavior Margarine Adverse Effects Random Allocation Rats, Sprague-Dawley Weight Loss Comparative Study Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Pharmacology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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