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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Miao, Jianting Qu, Jie Du, Ying Zhang, Wei Xi, Ye Zhang, Zhuo Li, Zhuyi Bai, Miao Zhou, Qiong |
| Description | Author Affiliation: Qu J ( Department of Neurology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.) |
| Abstract | BACKGROUND AND PURPOSE: Chronic cerebral hypoperfusion is a critical causative factor for the development of cognitive decline and dementia in the elderly, which involves many pathophysiological processes. Consequently, inhibition of several pathophysiological pathways is an attractive therapeutic strategy for this disorder. Rutin, a biologically active flavonoid, protects the brain against several insults through its antioxidant and anti-inflammatory properties, but its effect on cognitive deficits and brain damage caused by chronic cerebral hypoperfusion remains unknown. Here, we investigated the neuroprotective effect of rutin on cognitive impairments and the potential mechanisms underlying its action in rats with chronic cerebral hypoperfusion. EXPERIMENTAL APPROACH: We used Sprague-Dawley rats with permanent bilateral common carotid artery occlusion (BCCAO), a well-established model of chronic cerebral hypoperfusion. After rutin treatment for 12 weeks, the neuroprotective effect of rutin in rats was evaluated by behavioural tests, biochemical and histopathological analyses. KEY RESULTS: BCCAO rats showed marked cognitive deficits, which were improved by rutin treatment. Moreover, BCCAO rats exhibited central cholinergic dysfunction, oxidative damage, inflammatory responses and neuronal damage in the cerebral cortex and hippocampus, compared with sham-operated rats. All these effects were significantly alleviated by treatment with rutin. CONCLUSION AND IMPLICATIONS: Our results provide new insights into the pharmacological actions of rutin and suggest that rutin has multi-targeted therapeutical potential on cognitive deficits associated with conditions with chronic cerebral hypoperfusion such as vascular dementia and Alzheimer's disease. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 15 |
| Volume Number | 171 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 2014-08-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Brain Ischemia Drug Therapy Cognition Disorders Neuroprotective Agents Therapeutic Use Rutin Acetylcholine Metabolism Animals Astrocytes Drug Effects Avoidance Learning Cerebral Cortex Cytokines Glutathione Peroxidase Hippocampus Malondialdehyde Maze Learning Microglia Neurons Pathology Pharmacology Oxidative Stress Rats, Sprague-Dawley Superoxide Dismutase Research Support, Non-U.S. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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