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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sumners, C. Nair, A. Horowitz, A. Oswalt, A. Francis, J. Steckelings, U. M. Rathinasabapathy, A. Bruce, E. Katovich, M. J. Unger, T. Raizada, M. K. Shenoy, V. Espejo, A. |
| Description | Author Affiliation: Bruce E ( Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA.) |
| Abstract | BACKGROUND AND PURPOSE: Pulmonary hypertension (PH) is a devastating disease characterized by increased pulmonary arterial pressure, which progressively leads to right-heart failure and death. A dys-regulated renin angiotensin system (RAS) has been implicated in the development and progression of PH. However, the role of the angiotensin AT2 receptor in PH has not been fully elucidated. We have taken advantage of a recently identified non-peptide AT2 receptor agonist, Compound 21 (C21), to investigate its effects on the well-established monocrotaline (MCT) rat model of PH. EXPERIMENTAL APPROACH: A single s.c. injection of MCT (50 mg·kg(-1) ) was used to induce PH in 8-week-old male Sprague Dawley rats. After 2 weeks of MCT administration, a subset of animals began receiving either 0.03 mg·kg(-1) C21, 3 mg·kg(-1) PD-123319 or 0.5 mg·kg(-1) A779 for an additional 2 weeks, after which right ventricular haemodynamic parameters were measured and tissues were collected for gene expression and histological analyses. KEY RESULTS: Initiation of C21 treatment significantly attenuated much of the pathophysiology associated with MCT-induced PH. Most notably, C21 reversed pulmonary fibrosis and prevented right ventricular fibrosis. These beneficial effects were associated with improvement in right heart function, decreased pulmonary vessel wall thickness, reduced pro-inflammatory cytokines and favourable modulation of the lung RAS. Conversely, co-administration of the AT2 receptor antagonist, PD-123319, or the Mas antagonist, A779, abolished the protective actions of C21. CONCLUSIONS AND IMPLICATIONS: Taken together, our results suggest that the AT2 receptor agonist, C21, may hold promise for patients with PH. |
| ISSN | 00071188 |
| e-ISSN | 14765381 |
| Journal | British Journal of Pharmacology |
| Issue Number | 9 |
| Volume Number | 172 |
| Language | English |
| Publisher | Wiley Online Library(on behalf of The British Pharmacological Society) |
| Publisher Date | 2015-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Cardiovascular Agents Pharmacology Hypertension, Pulmonary Prevention & Control Hypertrophy, Right Ventricular Lung Drug Effects Myocardium Pulmonary Fibrosis Receptor, Angiotensin, Type 2 Agonists Ventricular Dysfunction, Right Angiotensin II Analogs & Derivatives Angiotensin II Type 2 Receptor Blockers Animals Disease Models, Animal Fibrosis Hemodynamics Chemically Induced Metabolism Pathology Physiopathology Imidazoles Monocrotaline Peptide Fragments Proto-Oncogene Proteins Antagonists & Inhibitors Pyridines Rats, Sprague-Dawley Receptors, G-Protein-Coupled Signal Transduction Vascular Remodeling Ventricular Function, Right Ventricular Remodeling Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
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