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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Winik, B. Levstein, P. R. Gennaro, A. M. Frías, M. A. Disalvo, E. A. Franzoni, M. B. Nicastro, A. Diaz, S. B. |
| Description | Author Affiliation: Frías MA ( Instituto de Química Física, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, San Lorenzo 456 (4000) Tucumán, Argentina.) |
| Abstract | Arbutin is known to suppress melanin production in murine B16 melanoma cells and inhibit phospholipase action. This encourages the possibility to stabilize it in lipid aggregates for its administration in medical applications. Thus, it was of interest to demonstrate that monomyristoylphosphatidylcholine (14:0 lysoPC) and arbutin may form association complexes. This was studied by Electron Microscopy (EM), $^{31}P$ Nuclear Magnetic Resonance $(^{31}P$ NMR), Electronic Paramagnetic Resonance (EPR) and Fourier Transform Infrared Spectroscopy (FTIR). EM images show the formation of particles of c.a. 6 nm in diameter. For a 1:1 lysoPC–arbutin molar ratio $^{31}P$ NMR shows a spectrum with a shoulder that resembles the axially symmetric spectrum characteristic of vesicles. The addition of $La^{3+}$ ions to the arbutin–lysoPC complex allows one to distinguish two phosphorous populations. These results suggest that arbutin–lysoPC forms vesicles with bilayers stabilized in an interdigitated array. FTIR spectroscopy shows that arbutin interacts with the hydrated population of the carbonyl groups and with the phosphates through the formation of hydrogen bonds. It is interpreted that hydrophobic interactions among the phenol group of arbutin and the acyl chain of lysoPC are responsible for the decrease in acyl chain mobility observed at the 5th C level by EPR. A model proposing the formation of interdigitated bilayers of arbutin-lysoPC could explain the experimental results. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 5 |
| Volume Number | 1778 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Arbutin Chemistry Lipid Bilayers Lysophosphatidylcholines Animals Cell Line, Tumor Electron Spin Resonance Spectroscopy Magnetic Resonance Spectroscopy Mice Microscopy, Electron, Transmission Spectroscopy, Fourier Transform Infrared Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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