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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ceci, Pierpaolo Chiancone, Emilia Pasquali, Paolo Ammendola, Serena Pacello, Francesca Battistoni, Andrea |
| Description | Author Affiliation: Pacello F ( Dipartimento di Biologia, Universitá di Roma Tor Vergata, Via della Ricerca Scientifica, 00133 Roma, Italy.) |
| Abstract | Several bacteria possess periplasmic Cu,Zn superoxide dismutases which can confer protection from extracellular reactive oxygen species. Thus, deletion of the sodC1 gene reduces Salmonella enterica serovar Typhimurium ability to colonize the spleens of wild type mice, but enhances virulence in p47phox mutant mice. To look into the role of periplamic Cu,Zn superoxide dismutase and into possible additive effects of the ferritin-like Dps protein involved in hydrogen peroxide detoxification, we have analyzed bacterial survival in response to extracellular sources of superoxide and/or hydrogen peroxide. Exposure to extracellular superoxide of Salmonella Typhimurium mutant strains lacking the sodC1 and sodC2 genes and/or the dps gene does not cause direct killing of bacteria, indicating that extracellular superoxide is poorly bactericidal. In contrast, all mutant strains display a sharp hydrogen peroxide-dependent loss of viability, the dps , sodC1 , sodC2 mutant being less resistant than the dps or the sodC1 , sodC2 mutants. These findings suggest that the role of Cu,Zn superoxide dismutase in bacteria is to remove rapidly superoxide from the periplasm to prevent its reaction with other reactive molecules. Moreover, the nearly additive effect of the sodC and dps mutations suggests that localization of antioxidant enzymes in different cellular compartments is required for bacterial resistance to extracytoplasmic oxidative attack. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 2 |
| Volume Number | 1780 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-02-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Bacterial Proteins Physiology DNA-Binding Proteins Respiratory Burst Salmonella Typhimurium Superoxide Dismutase Animals Genetics Cytoplasm Metabolism Hydrogen Peroxide Pharmacology Mice Mutation Phagocytosis Reactive Oxygen Species Drug Effects Superoxides Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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