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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tapia, Tenekua Mallik, Ipsita Davila, Monica Schanen, Brian Chakrabarti, Ratna |
| Description | Author Affiliation: Mallik I ( Department of Molecular Biology and Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, USA.) |
| Abstract | Androgen receptor plays a critical role in the development and maintenance of cancers in the prostate. Earlier, we have shown that Cdc6, a regulatory protein for initiation of DNA replication, is down regulated in androgen-insensitive prostate cancer cells. In this report, we studied the involvement of androgen, mediated through androgen receptor (AR) in regulation of Cdc6 expression. Our results demonstrated that androgen treatment stimulated Cdc6 expression in xenograft tumors and androgen-sensitive prostate cancer cells. We also showed that androgen treatment stimulated Cdc6 transcription through possible interaction of AR with the ARE sequence in the Cdc6 promoter and that the stimulatory effect of androgen required intact E2F binding sites in the promoter. Androgen treatment differentially altered nuclear availability of E2F1 and E2F3, and increased the amount of hypophosphorylated retinoblastoma protein (pRb) in the nucleus in a time dependent fashion. We further showed that AR interacted with E2F transcription factors in a ligand-independent manner and that ligand-bound AR was less efficient in interacting with E2F proteins. DNA–protein interaction assays indicated that androgen treatment altered binding of E2F1 to the Cdc6 promoter in prostate cancer cells. We conclude that AR regulates Cdc6 transcription through interaction with the Cdc6 promoter, and complex formation with E2F1 and E2F3 in a differential manner. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 10 |
| Volume Number | 1783 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-10-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Androgens Metabolism Cell Cycle Proteins E2F Transcription Factors Nuclear Proteins Prostatic Neoplasms Receptors, Androgen Transcription, Genetic Genetics Binding Sites Cell Line, Tumor Cell Nucleus Promoter Regions, Genetic Protein Binding Up-Regulation Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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