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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Vaseva, Angelina V. Moll, Ute M. |
| Description | Author Affiliation: Vaseva AV ( Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA.) |
| Abstract | p53 is one of the most mutated tumor suppressors in human cancers and as such has been intensively studied for a long time. p53 is a major orchestrator of the cellular response to a broad array of stress types by regulating apoptosis, cell cycle arrest, senescence, DNA repair and genetic stability. For a long time it was thought that these functions of p53 solely rely on its function as a transcription factor, and numerous p53 target genes have been identified [1]. In the last 8 years however, a novel transcription-independent proapoptotic function mediated by the cytoplasmic pool of p53 has been revealed. p53 participates directly in the intrinsic apoptosis pathway by interacting with the multidomain members of the Bcl-2 family to induce mitochondrial outer membrane permeabilization. Our review will discuss these studies, focusing on recent advances in the field. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 5 |
| Volume Number | 1787 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Genes, Tumor Suppressor Mitochondria Physiology Neoplasms Genetics Tumor Suppressor Protein P53 Apoptosis Brain Ischemia Pathology Cell Death Gene Expression Regulation, Neoplastic Genes, Bcl-2 Kidney Diseases Physiopathology Protein Transport Reperfusion Injury Transcription, Genetic Metabolism Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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