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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Vandenbranden, Michel Lensink, Marc F. Ruysschaert, Jean-marie Lonez, Caroline |
| Description | Author Affiliation: Lonez C ( Laboratoire de Structure et Fonction des Membranes Biologiques, Centre de Biologie Structurale et de Bioinformatique, CP 206/2, Université Libre de Bruxelles, Campus Plaine, Boulevard du Triomphe, B-1050 Brussels, Belgium.) |
| Abstract | Cationic lipids have been extensively used as carriers of biologically active molecules (nucleic acids, peptides and proteins) into cells. Recent data provided evidence that cationic lipids are not just inert transporters but do activate specific cellular cascades. This review illustrates these activating properties with a few examples. Cell activation raises the question of which receptors are involved. Some cationic lipids seem to satisfy specific structural requirements of Toll-like receptors (TLR4) as they activate TLR4-dependent pathways. However, cationic lipids display a large structural diversity and it is likely that they are also recognized by receptors with a broader specificity. Alternatives are proposed and discussed to explain this broad specificity. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 6 |
| Volume Number | 1790 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-06-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Cations Metabolism Lipid Metabolism Lipids Chemistry Signal Transduction Physiology Integrins Lymphocyte Antigen 96 Mitogen-Activated Protein Kinases Toll-Like Receptor 4 Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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