NDLI: Telomerase and DNA repair in glioma

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Patel, R. Shervington, A.
Description	Author Affiliation: Patel R ( Faculty of Science and Technology, University of Central Lancashire, Preston, PR1 2HE, UK.)
Abstract	Both DNA repair (MGMT) and immortalisation (telomerase) have been linked to the root of cancer. In glioma, MGMT expression is negatively regulated through promoter methylation and its absence is associated with enhanced chemosensitivity. However, recent studies indicate that telomerase is positively regulated through methylation and its elimination enhances chemotherapy. These observations suggest that suppression of telomerase in combination with MGMT may have additional anti-proliferative and anti-apoptotic effects, which may lead to increased patient survival rates. However, different approaches may be required to compliment the epigenetic events that regulate these genes. Nevertheless, given that median survival of glioma patients is less than a year, this review focuses on the recent approaches used to target MGMT and telomerase, with a view to increase life expectancy of patients while limiting side effects.
ISSN	00063002
Journal	Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Issue Number	4
Volume Number	1792
Language	English
Publisher	Elsevier
Publisher Date	2009-04-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	DNA Methylation DNA Repair Glioma Enzymology Promoter Regions, Genetic Telomerase Metabolism Animals Drug Therapy Mortality Life Expectancy Survival Rate Research Support, Non-U.S. Gov't Biochemistry
Content Type	Text
Resource Type	Article

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