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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Moye-rowley, W. Scott Shahi, Puja |
| Description | Author Affiliation: Shahi P ( Department of Molecular Physiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.) |
| Abstract | Pathogenic fungi present a special problem in the clinic as the range of drugs that can be used to treat these types of infections is limited. This situation is further complicated by the presence of robust inducible gene networks encoding different proteins that confer tolerance to many available antifungal drugs. The transcriptional control of these multidrug resistance systems in several key fungi will be discussed. Experiments in the non-pathogenic Saccharomyces cerevisiae have provided much of our current understanding of the molecular framework on which fungal multidrug resistance is built. More recent studies on the important pathogenic Candida species, Candida albicans and Candida glabrata, have provided new insights into the organization of the multidrug resistance systems in these organisms. We will compare the circuitry of multidrug resistance networks in these three organisms and suggest that, in addition to the well-accepted drug efflux activities, the regulation of membrane composition by multidrug resistance proteins provides an important contribution to the resistant phenotypes observed. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 5 |
| Volume Number | 1794 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2009-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Candida Albicans Genetics Drug Resistance, Multiple, Fungal Physiology Lipids Chemistry P-Glycoproteins Saccharomyces Cerevisiae Transcription Factors ATP-Binding Cassette Transporters DNA-Binding Proteins Genes, Fungal Drug Effects Phospholipids Metabolism Saccharomyces Cerevisiae Proteins Sphingolipids Transcription, Genetic Research Support, N.I.H., Extramural Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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