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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lee, Seon Ho Park, Jeong Woo Ko, Myoung Seok Cho, Wha Ja Kim, Hong Kyung Lee, Byung Ju Kim, Hyo Jeong |
| Description | Author Affiliation: Kim HJ ( Department of Biological Sciences, University of Ulsan, Ulsan 680-749, Korea.) |
| Abstract | Developmentally regulated GTP-binding protein 2 (DRG2) is an evolutionarily conserved GTP-binding protein. DRG2 mRNA expression has been confirmed in many animal and human tissues. DRG2 is thought to play an essential role in the control of cell growth and differentiation. However, transcriptional regulation of DRG2 is largely unknown. To investigate the mechanisms controlling DRG2 expression, we cloned 1509 bp of the 5′-flanking sequence of this gene. Deletion analysis showed that the region between −113 and −70 is essential for the basal level expression of the DRG2 gene in K562 human erythroleukemic cells. Mutation of a putative stimulating protein 1 (Sp1) regulatory site located at position −108 resulted in a significant decline in DRG2 promoter activity. Electrophoretic mobility shift assay and chromatin immunoprecipitation analysis revealed that Sp1 binds to this site. Knockdown of Sp1 expression using siRNA inhibited the promoter activation as well as the endogenous DRG2 transcriptional level. Taken together, these results demonstrate that basal expression level of DRG2 is regulated by the Sp1 transcription factor. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 3 |
| Volume Number | 1809 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | GTP-Binding Proteins Genetics Sp1 Transcription Factor Metabolism Transcription, Genetic Binding Sites Cell Survival DNA Mutational Analysis Gene Expression Regulation Gene Silencing K562 Cells Molecular Sequence Data Mutation Promoter Regions, Genetic Protein Binding Sequence Deletion Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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