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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Amara, Sawsan Record, Michel Prestwich, Glenn D. Carrière, Frédéric Ferrato, Francine Jiang, Guowei Subra, Caroline |
| Description | Author Affiliation: Record M ( Cancer Research Center of Toulouse, Université Toulouse 3, France. michel.record@inserm.fr) |
| Abstract | The interfacial physical properties of bis(monoacylglycero)phosphate (BMP) and its derivatives with three oleoyl chains (hemi-BDP) and four oleoyl chains (bis(diacylglycero)phosphate, BDP) were investigated using Langmuir monomolecular films. The mean molecular area of BMP at the collapse surface pressure (45 mN $m^{− 1})$ was similar to those measured with other phospholipids bearing two acyl chains (66 and $59.6 Å^{2}$ $molecule^{− 1}$ at pH 5.5 and 8.0, respectively). In Hemi-BDP and BDP, the mean molecular area increased by 26 and $35 Å^{2}$ $molecule^{− 1}$ per additional acyl chain at pH 5.5 and 8.0, respectively. When BMP was added to a phospholipid mixture mimicking late endosome membrane composition at pH 8.0, the mean phospholipid molecular area increased by 7% regardless of the surface pressure. In contrast, the variation in molecular area was surface pressure-dependent at pH 5.5, a pH value close to that of intra-endosomal content. BMP and hemi-BDP, but not BDP, were hydrolyzed by pancreatic lipase-related protein 2 (PLRP2), which exhibits phospholipase $A_{1}$ activity. At pH 5.5, the maximum activities of PLRP2 on BMP were recorded at high surface pressures (25–35 mN/m). At pH 8.0, the PLRP2 activity vs. surface pressure showed a bell-shaped curve with maximum activities at 15 mN/m for both BMP and hemi-BDP. This is a new activity for this enzyme which could degrade cellular BMP since both human PLRP2 (HPLRP2) and BMP were localized in human monocytic THP-1 cells. This is the first report on the cellular localization of HPLRP2 in human monocytes. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 7-8 |
| Volume Number | 1811 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-07-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Lipase Metabolism Lysophospholipids Pharmacology Monoglycerides Biophysical Phenomena Cell Line DNA, Complementary Genetics Endosomes Hydrogen-Ion Concentration Hydrolysis Immunohistochemistry Lipolysis Chemistry Molecular Structure Monocytes Drug Effects Phosphatidic Acids Recombinant Proteins Unilamellar Liposomes Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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