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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Casafont, Iñigo Rojas, Ana M. Valencia, Alfonso Palczewska, Malgorzata Ghimire, Kedar Mellström, Britt Lafarga, Miguel Naranjo, Jose R. |
| Description | Author Affiliation: Palczewska M ( Centro Nacional de Biotecnología, CSIC, Madrid, Spain.) |
| Abstract | DREAM is a $Ca^{2+}-binding$ protein with specific functions in different cell compartments. In the nucleus, DREAM acts as a transcriptional repressor, although the mechanism that controls its nuclear localization is unknown. Yeast two-hybrid assay revealed the interaction between DREAM and the SUMO-conjugating enzyme Ubc9 and bioinformatic analysis identified four sumoylation-susceptible sites in the DREAM sequence. Single K-to-R mutations at positions K26 and K90 prevented in vitro sumoylation of recombinant DREAM. DREAM sumoylation mutants retained the ability to bind to the DRE sequence but showed reduced nuclear localization and failed to regulate DRE-dependent transcription. In PC12 cells, sumoylated DREAM is present exclusively in the nucleus and neuronal differentiation induced nuclear accumulation of sumoylated DREAM. In fully differentiated trigeminal neurons, DREAM and SUMO-1 colocalized in nuclear domains associated with transcription. Our results show that sumoylation regulates the nuclear localization of DREAM in differentiated neurons. This article is part of a Special Issue entitled: 11th European Symposium on Calcium. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 5 |
| Volume Number | 1813 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Cell Nucleus Metabolism Kv Channel-Interacting Proteins Repressor Proteins Sumoylation Amino Acid Sequence Animals Cell Differentiation DNA Mutational Analysis HEK293 Cells HeLa Cells Chemistry Mice Molecular Sequence Data Mutant Proteins Neurons Cytology PC12 Cells Protein Binding Protein Transport SUMO-1 Protein Sequence Alignment Trigeminal Nerve Ultrastructure Ubiquitin-Conjugating Enzymes Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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