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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Fantuzzi, Andrea Sadeghi, Sheila J. Gilardi, Gianfranco |
| Description | Author Affiliation: Sadeghi SJ ( Department of Human and Animal Biology, University of Turin, Italy.) |
| Abstract | Improving the electrochemical performance of cytochrome P450 enzymes is highly desirable due to their versatility in the recognition of different biological and xenobiotic compounds. The task poses an exciting challenge because it leads not only to the acquisition of fundamental knowledge on the redox properties of these enzymes, but it also opens opportunities for technological and commercial applications. Interfacing these enzymes to electrode surfaces and electrochemically driving their catalytic cycle has proven to be very difficult. Initial attempts made by several groups included the direct immobilisation of these enzymes on electrode surfaces and omission of their redox partners for simplification of their electron transfer pathway. The data obtained in these cases generally resulted in a high heterogeneous electron transfer rate but without success in terms of detectable substrate turnover. The breakthrough in electrocatalysis has been made when both the electrode and the enzyme have been engineered, in some cases mimicking the natural environment of the microsomal enzymes and the inclusion of their electron transfer partners. This paper reviews and discusses the recent literature on this subject, and highlights the different approaches that have led to an unprecedented advancement of this area of research. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 1 |
| Volume Number | 1814 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Cytochrome P-450 Enzyme System Metabolism Electrochemical Techniques Biocatalysis Chemistry Instrumentation Electrodes Enzymes, Immobilized Models, Molecular Oxidation-Reduction Protein Conformation Protein Structure, Secondary Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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