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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | López-villarejo, Juan Martínez-del-pozo, Alvaro Diago-navarro, Elizabeth Herrero-galán, Elías Olmo, Nieves Díaz-orejas, Ramón Alvarez-garcía, Elisa García-ortega, Lucía Gavilanes, José G. |
| Description | Author Affiliation: Alvarez-García E ( Departamento de Bioquímica y Biología Molecular I, Facultad de Ciencias Químicas, Universidad Complutense, Madrid, Spain.) |
| Abstract | Fungal ribotoxins are toxic secreted ribonucleases that cleave a conserved single phosphodiester bond located at the sarcin/ricin loop of the larger rRNA. This cleavage inactivates ribosomes leading to protein biosynthesis inhibition and cell death. It has been proposed that interactions other than those found at the active site of ribotoxins are needed to explain their exquisite specific activity. The study presented shows the ability of a catalytically inactive α-sarcin mutant (H137Q) to bind eukaryotic ribosomes and interfere with in vitro protein biosynthesis. The results obtained are compatible with previous observations that α-sarcin can promote cell death by a mechanism that is independent of rRNA cleavage, expanding the potential set of activities performed by this family of toxins. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 10 |
| Volume Number | 1814 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-10-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Endoribonucleases Pharmacology Fungal Proteins Metabolism Protein Biosynthesis Drug Effects Protein Synthesis Inhibitors Animals Genetics Models, Biological Mutant Proteins Chemistry Protein Binding Rabbits Ribosomes Saccharomyces Cerevisiae Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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