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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hill, Bruce C. Andrews, Diann |
| Description | Author Affiliation: Hill BC ( Department of Biochemistry and Protein Function Discovery Group, Queen's University, Kingston, Ontario, Canada K7L 3N6. hillb@queensu.ca) |
| Abstract | SCO (synthesis of cytochrome c oxidase) proteins are involved in the assembly of the respiratory chain enzyme cytochrome c oxidase acting to assist in the assembly of the Cu $_{A}$ center contained within subunit II of the oxidase complex. The Cu $_{A}$ center receives electrons from the reductive substrate ferrocytochrome c, and passes them on to the cytochrome a center. Cytochrome a feeds electrons to the oxygen reaction site composed of cytochrome $a_{3}$ and Cu $_{B}$ . Cu $_{A}$ consists of two copper ions positioned within bonding distance and ligated by two histidine side chains, one methionine, a backbone carbonyl and two bridging cysteine residues. The complex structure and redox capacity of Cu $_{A}$ present a potential assembly challenge. SCO proteins are members of the thioredoxin family which led to the early suggestion of a disulfide exchange function for SCO in Cu $_{A}$ assembly, whereas the copper binding capacity of the Bacillus subtilis version of SCO (i.e., BsSCO) suggests a direct role for SCO proteins in copper transfer. We have characterized redox and copper exchange properties of apo- and metalated-BsSCO. The release of copper (II) from its complex with BsSCO is best achieved by reducing it to Cu(I). We propose a mechanism involving both disulfide and copper exchange between BsSCO and the apo-Cu $_{A}$ site. This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 6 |
| Volume Number | 1817 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-06-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Bacterial Proteins Chemistry Copper Electron Transport Complex IV Biosynthesis Membrane Proteins Dithiothreitol Hydrogen Peroxide Kinetics Oxidants Oxidation-Reduction Phosphines Protein Binding Reducing Agents Spectrophotometry Thioredoxins Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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