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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Van Vorst, Matthew P. Elliott, Gloria D. Vijayaraghavan, R. Weaver, Katherine D. Macfarlane, Douglas R. |
| Description | Author Affiliation: Weaver KD ( Department of Mechanical Engineering and Engineering Science, The University of North Carolina, Charlotte, NC 28223, USA.) |
| Abstract | To better understand the relationship between the relative cytotoxicity of diluted ionic liquids and their specific interaction with biological membranes, the thermotropic behavior of model lipid membrane systems formulated in a series of choline based organic salts was investigated. Unilamellar vesicles prepared from dipalmitoylphosphatidylcholine were exposed to a series of choline phosphate salts at a concentration of 10mM at pH7.40, and the gel to liquid-crystalline state transition was examined using differential scanning calorimetry. The choline salts that were observed to have a low relative toxicity in previous studies induced minimal changes in the lipid phase transition behavior of these model membranes. In contrast, the salts choline bis(2,4,4-trimethylpentyl)phosphinate and choline bis(2-ethylhexyl)phosphate, both of which were observed to have high relative toxicity, caused distinct disruptions in the lipid phase transition behavior, consistent with penetration of the salts into the acyl chains of the phospholipids. choline bis(2,4,4-trimethylpentyl)phosphinate reduced the Tm and enthalpy of the main transition of dipalmitoylphosphatidylcholine while choline bis(2-ethylhexyl)phosphate induced the equilibration of alternate phases. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 8 |
| Volume Number | 1828 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-08-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Choline Metabolism Lipid Bilayers Membrane Lipids Membranes, Artificial Calorimetry, Differential Scanning Chemistry Magnetic Resonance Spectroscopy Phase Transition Temperature Thermodynamics Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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