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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Layat, Elodie Tourmente, Sylvette Probst, Aline V. |
| Description | Author Affiliation: Layat E ( GReD, CNRS UMR6293, Clermont Université, INSERM U1103, 24 avenue des Landais 63171 Cedex Aubière, France. elodie.layat@upmc.fr) |
| Abstract | Transcription Factor IIIA (TFIIIA) is specifically required for transcription of 5S ribosomal RNA, an essential component of the ribosome. The TFIIIA protein, found in every organism, has been characterized in several species. It shows remarkably poor conservation of primary protein sequence, but all orthologues analyzed carry several C2H2-zinc fingers that are required for TFIIIA binding to both 5S ribosomal DNA (rDNA) and RNA (rRNA). Alignments of TFIIIA protein and 5S rRNA gene sequences suggest a parallel evolution of the transcription factor and its natural binding site, the internal control region of the 5S rRNA gene. We discuss here how TFIIIA expression and availability in the cell is tightly regulated at the transcriptional, post-transcriptional and post-translational level to ensure adequate amounts of TFIIIA protein depending on cell type and developmental stage. This article is part of a Special Issue entitled: Transcription by Odd Pols. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 3-4 |
| Volume Number | 1829 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Transcription Factor TFIIIA Chemistry Transcription, Genetic Animals Arabidopsis Genetics Metabolism Evolution, Molecular RNA, Ribosomal, 5S Sequence Homology, Amino Acid Xenopus Zinc Fingers Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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