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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pham, Tho X. Kang, Insoo Ku, Chai Siah Park, Youngki Shin, Min Sun Lee, Jiyoung Kim, Bohkyung |
| Description | Author Affiliation: Ku CS ( Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.) |
| Abstract | BACKGROUND: Chronic inflammation contributes to the development of pathological disorders including insulin resistance and atherosclerosis. Identification of anti-inflammatory natural products can prevent the inflammatory diseases. METHODS: Anti-inflammatory effects of blue-green algae (BGA), i.e., Nostoc commune var. sphaeroides Kützing (NO) and Spirulina platensis (SP), were compared in RAW 264.7 and mouse bone marrow-derived macrophages (BMM) as well as splenocytes from apolipoprotein E knockout (apoE(-/-)) mice fed BGA. RESULTS: When macrophages pretreated with 100µg/ml NO lipid extract (NOE) or SP lipid extract (SPE) were activated by lipopolysaccharide (LPS), expression and secretion of pro-inflammatory cytokines, such as tumor necrosis factor (TNF ), interleukin 1ß (IL-1ß), and IL-6, were significantly repressed. NOE and SPE also significantly repressed the expression of TNF and IL-1ß in BMM. LPS-induced secretion of IL-6 was lower in splenocytes from apoE(-/-) fed an atherogenic diet containing 5% NO or SP for 12weeks. In RAW 264.7 macrophages, NOE and SPE markedly decreased nuclear translocation of NF-κB. The degree of repression of pro-inflammatory gene expression by algal extracts was much stronger than that of SN50, an inhibitor of NF-κB nuclear translocation. Trichostatin A, a pan histone deacetylase inhibitor, increased basal expression of IL-1ß and attenuated the repression of the gene expression by SPE. SPE significantly down-regulated mRNA abundance of 11 HDAC isoforms, consequently increasing acetylated histone 3 levels. CONCLUSION: NOE and SPE repress pro-inflammatory cytokine expression and secretion in macrophages and splenocytes via inhibition of NF-κB pathway. Histone acetylation state is likely involved in the inhibition. GENERAL SIGNIFICANCE: This study underscores natural products can exert anti-inflammatory effects by epigenetic modifications such as histone acetylation. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 4 |
| Volume Number | 1830 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-04-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Cyanobacteria Physiology Cytokines Biosynthesis Macrophages Immunology NF-kappa B Antagonists & Inhibitors Spleen Cytology Active Transport, Cell Nucleus Animals Cells, Cultured Histone Deacetylases Histones Metabolism Mice Mice, Inbred C57BL Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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