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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Huang, Chun-yin Hou, Sheng-mou Liu, Ju-fang Tsai, Chun-hao Hsu, Chin-jung Tang, Chih-hsin |
| Description | Author Affiliation: Liu JF ( Central Laboratory, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.) |
| Abstract | CCN4 is a cysteine-rich protein that belongs to the Cyr61, CTGF, Nov family of matricellular proteins. Here, we investigated the intracellular signaling pathways involved in CCN4-induced vascular cell adhesion molecule-1 expression in human osteoarthritis synovial fibroblasts. Stimulation of OASFs with CCN4 induced VCAM-1 expression. CCN4-induced VCAM-1 expression was attenuated by αvβ5 or α6β1 integrin antibody, Syk inhibitor, PKCδ inhibitor (rottlerin), JNK inhibitor (SP600125), and AP-1 inhibitors (curcumin and tanshinone). Stimulation of cells with CCN4 increased Syk, PKCδ, and JNK activation. Treatment of OASFs with CCN4 also increased c-Jun phosphorylation, AP-1-luciferase activity, and c-Jun binding to the AP-1 element in the VCAM-1 promoter. Moreover, up-regulation of VCAM-1 increased the adhesion of monocytes to OASF monolayers, and this adhesion was attenuated by transfection with a VCAM-1 siRNA. Our results suggest that CCN4 increases VCAM-1 expression in human OASFs via the Syk, PKCδ, JNK, c-Jun, and AP-1 signaling pathways. The CCN4-induced VCAM-1 expression promoted monocyte adhesion to human OASFs. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 5 |
| Volume Number | 1833 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Osteoarthritis Synovial Fluid Vascular Cell Adhesion Molecule-1 Metabolism CCN Intercellular Signaling Proteins Genetics Cell Adhesion Connective Tissue Growth Factor Cysteine-Rich Protein 61 Fibroblasts Cytology Pathology Gene Expression Regulation Monocytes Nephroblastoma Overexpressed Protein Proto-Oncogene Proteins Signal Transduction Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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