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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hu, Wenzhong Xiong, Wen Wang, Lina Qu, Xiaojing Fan, Shengdi Quan, Chunshan |
| Description | Author Affiliation: Wang L ( Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhong-shan Road, Dalian 116023, China. Electronic address: wanglina.gucas@hotmail.com.); Quan C ( Department of Life Science, Dalian Nationalities University, Economical and Technological Development Zone, Dalian 116600, China); Xiong W ( Department of Life Science, Dalian Nationalities University, Economical and Technological Development Zone, Dalian 116600, China); Qu X ( Department of Life Science, Dalian Nationalities University, Economical and Technological Development Zone, Dalian 116600, China); Fan S ( Department of Life Science, Dalian Nationalities University, Economical and Technological Development Zone, Dalian 116600, China); Hu W ( Department of Life Science, Dalian Nationalities University, Economical and Technological Development Zone, Dalian 116600, China) |
| Abstract | Staphylococcus aureus accessory gene regulator ( agr ) locus controls the expression of virulence factors through a classical two-component signal transduction system that consists of a receptor histidine protein kinase AgrC and a cytoplasmic response regulator AgrA. An autoinducing peptide (AIP) encoded by agr locus activates AgrC, which transduces extracellular signals into the cytoplasm. Despite extensive investigations to identify AgrC–AIP interaction sites, precise signal recognition mechanisms remain unknown. This study aims to clarify the membrane topology of AgrC by applying the green fluorescent protein (GFP) fusion technique and the substituted cysteine accessibility method (SCAM). However, our findings were inconsistent with profile obtained previously by alkaline phosphatase. We report the topology of AgrC shows seven transmembrane segments, a periplasmic N-terminus, and a cytoplasmic C-terminus. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 3 |
| Volume Number | 1838 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Bacterial Proteins Chemistry Metabolism Cell Membrane Cysteine Green Fluorescent Proteins Protein Kinases Amino Acid Sequence Amino Acid Substitution Blotting, Western Fluorescence Molecular Sequence Data Phosphorylation Protein Binding Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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