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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kawazoe, Kazuyoshi Miyamoto, Licht Hatano, Aya Ishizawa, Keisuke Tsuchiya, Koichiro Tomita, Shuhei Yagi, Yuko Minakuchi, Kazuo |
| Description | Author Affiliation: Miyamoto L ( Laboratory of Pharmacology and Physiological Sciences, Frontier Laboratory for Pharmaceutical Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School, 1-78-1, Sho-machi, Tokushima 770-8505, Japan); Yagi Y ( Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, 1-78-1, Sho-machi, Tokushima 770-8505, Japan); Hatano A ( Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.); Kawazoe K ( Department of Clinical Pharmacy, Institute of Health Biosciences, The University of Tokushima Graduate School, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.); Ishizawa K ( Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.); Minakuchi K ( Department of Clinical Pharmacy, Institute of Health Biosciences, The University of Tokushima Graduate School, 1-78-1, Sho-machi, Tokushima 770-8505, Japan.); Tomita S ( Division of Molecular Pharmacology, Tottori University Faculty of Medicine, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan.); Tsuchiya K ( Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, 1-78-1, Sho-machi, Tokushima 770-8505, Japan. Electronic address: tsuchiya@tokushima-u.ac.jp.) |
| Abstract | Background Oxygen is important for common eukaryotic cells to generate ATP. Pathophysiological conditions such as ischemic diseases cause tissue hypoxia. In addition, oxygen availability in deep tissues is supposed to be far lower than surrounding atmosphere even in healthy animals, and the oxygen partial pressures in most normal tissues are estimated to be around 40–50 mmHg, so-called mild hypoxia. Recent studies have demonstrated that mild hypoxia has distinct effects on living cells from severe hypoxia. For instance, mild hypoxia was reported to promote cell reprogramming. Although severe hypoxia is known to inhibit cell proliferation, mild hypoxia has been paradoxically demonstrated to increase cell proliferation. However, it has not been clarified by which molecular mechanisms mild hypoxia evokes the discontinuous increment of cell proliferation. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 4 |
| Volume Number | 1850 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-04-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Cell Hypoxia Extracellular Signal-Regulated MAP Kinases Physiology MAP Kinase Signaling System Mitogen-Activated Protein Kinase Kinases Caco-2 Cells Cell Proliferation Cellular Reprogramming Phosphorylation Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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