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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Laurence, Ted A. Voss, John C. Altman, Robin Maezawa, Izumi Hideg, Kálmán Petrlova, Jitka Hilt, Silvia Kálai, Tamás Jin, Lee-way Ly, Sonny |
| Description | Author Affiliation: Altman R ( Department of Biochemistry & Molecular Medicine, University of California Davis, Davis CA 95616, USA.); Ly S ( Physical and Life Science Directorate, Lawrence Livermore National Laboratory, Livermore CA 94550, USA.); Hilt S ( Department of Biochemistry & Molecular Medicine, University of California Davis, Davis CA 95616, USA.); Petrlova J ( Department of Biochemistry & Molecular Medicine, University of California Davis, Davis CA 95616, USA.); Maezawa I ( M.I.N.D. Institute and Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento CA 95817, USA.); Kálai T ( Institute of Organic and Medicinal Chemistry, University of Pécs, H-7624 Pécs, Szigeti st. 12. Pécs, Hungary.); Hideg K ( Institute of Organic and Medicinal Chemistry, University of Pécs, H-7624 Pécs, Szigeti st. 12. Pécs, Hungary.); Jin LW ( M.I.N.D. Institute and Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento CA 95817, USA.); Laurence TA ( Physical and Life Science Directorate, Lawrence Livermore National Laboratory, Livermore CA 94550, USA.); Voss JC ( Department of Biochemistry & Molecular Medicine, University of California Davis, Davis CA 95616, USA. Electronic address: jcvoss@ucdavis.edu.) |
| Abstract | Alzheimer's disease is characterized by the presence of extracellular plaques comprised of amyloid beta (Aβ) peptides. Soluble oligomers of the Aβ peptide underlie a cascade of neuronal loss and dysfunction associated with Alzheimer's disease. Single particle analyses of Aβ oligomers in solution by fluorescence correlation spectroscopy (FCS) were used to provide real-time descriptions of how spin-labeled fluorenes (SLFs; bi-functional small molecules that block the toxicity of Aβ) prevent and disrupt oligomeric assemblies of Aβ in solution. Furthermore, the circular dichroism (CD) spectrum of untreated Aβ shows a continuous, progressive change over a 24-hour period, while the spectrum of Aβ treated with SLF remains relatively constant following initial incubation. These findings suggest the conformation of Aβ within the oligomer provides a complementary determinant of Aβ toxicity in addition to oligomer growth and size. Although SLF does not produce a dominant state of secondary structure in Aβ, it does induce a net reduction in beta secondary content compared to untreated samples of Aβ. The FCS results, combined with electron paramagnetic resonance spectroscopy and CD spectroscopy, demonstrate SLFs can inhibit the growth of Aβ oligomers and disrupt existing oligomers, while retaining Aβ as a population of smaller, yet largely disordered oligomers. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 12 |
| Volume Number | 1854 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-12-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Amyloid Beta-Peptides Chemistry Fluorenes Spin Labels Cell Line Circular Dichroism Protein Structure, Secondary Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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