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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sommer, Dayn Joseph Vaughn, Michael David Tomlin, John Clark, Brett Colby Roy, Anindya Ghirlanda, Giovanna |
| Description | Author Affiliation: Sommer DJ ( Department of Chemistry and Biochemistry, Box 871604, Arizona State University, Tempe, AZ 85287-1604, USA. Electronic address: djsomme1@asu.edu.); Vaughn MD ( Department of Chemistry and Biochemistry, Box 871604, Arizona State University, Tempe, AZ 85287-1604, USA. Electronic address: mdvaughn@asu.edu.); Clark BC ( Department of Chemistry and Biochemistry, Box 871604, Arizona State University, Tempe, AZ 85287-1604, USA. Electronic address: bcclark1@asu.edu.); Tomlin J ( Department of Chemistry and Biochemistry, Box 871604, Arizona State University, Tempe, AZ 85287-1604, USA. Electronic address: jjtomlin@asu.edu.); Roy A ( Department of Chemistry and Biochemistry, Box 871604, Arizona State University, Tempe, AZ 85287-1604, USA. Electronic address: aroy10@uw.edu.); Ghirlanda G ( Department of Chemistry and Biochemistry, Box 871604, Arizona State University, Tempe, AZ 85287-1604, USA. Electronic address: gghirlanda@asu.edu.) |
| Abstract | Bioinspired, protein-based molecular catalysts utilizing base metals at the active are emerging as a promising avenue to sustainable hydrogen production. The protein matrix modulates the intrinsic reactivity of organometallic active sites by tuning second-sphere and long-range interactions. Here, we show that swapping Co-Protoporphyrin IX for Fe-Protoporphyrin IX in cytochrome $b_{562}$ results in an efficient catalyst for photoinduced proton reduction to molecular hydrogen. Further, the activity of wild type Co-cyt $b_{562}$ can be modulated by a factor of 2.5 by exchanging the coordinating methionine with alanine or aspartic acid. The observed turnover numbers (TON) range between 125 and 305, and correlate well with the redox potential of the Co-cyt $b_{562}$ mutants. The photosensitized system catalyzes proton reduction with high efficiency even under an aerobic atmosphere, implicating its use for biotechnological applications. This article is part of a Special Issue entitled Biodesign for Bioenergetics — the design and engineering of electronic transfer cofactors, proteins and protein networks, edited by Ronald L. Koder and J.L. Ross Anderson. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 5 |
| Volume Number | 1857 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-05-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Cytochrome b Group Escherichia Coli Proteins Hydrogen Metabolism Protein Engineering Catalysis Catalytic Domain Genetics Cobalt Chemistry Cytochromes c Escherichia Coli Enzymology Hydrogenase Models, Molecular Mutagenesis Protein Binding Protoporphyrins Synthetic Biology Research Support, U.S. Gov't, Non-P.H.S. Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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