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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ohn, Takbum Jayabalan, Aravinth K. Koh, Hyun Chul Ahn, Seyoung Hwang, Jungwook Park, Jungyun |
| Description | Author Affiliation: Park J ( Graduate School for Biomedical Science & Engineering, FTC1202-8, Hanyang University, 222 Wangimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea.); Ahn S ( Graduate School for Biomedical Science & Engineering, FTC1202-8, Hanyang University, 222 Wangimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea.); Jayabalan AK ( Department of Cellular and Molecular Medicine, College of Medicine, Chosun University, Gwangju, Republic of Korea.); Ohn T ( Department of Cellular and Molecular Medicine, College of Medicine, Chosun University, Gwangju, Republic of Korea.); Koh HC ( Department of Pharmacology, College of Medicine, Hanyang University, 222 Wangimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea. Electronic address: hckoh@hanyang.ac.kr.); Hwang J ( Graduate School for Biomedical Science & Engineering, FTC1202-8, Hanyang University, 222 Wangimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea) |
| Abstract | Nonsense-mediated mRNA decay (NMD) modulates the level of mRNA harboring a premature termination codon (PTC) in a translation-dependent manner. Inhibition of translation is known to impair NMD; however, few studies have investigated the correlation between enhanced translation and increased NMD. Here, we demonstrate that insulin signaling events increase translation, leading to an increase in NMD of eIF4E-bound transcripts. We provide evidence that (i) insulin-mediated enhancement of translation augments NMD and rapamycin abrogates this enhancement; (ii) an increase in AKT phosphorylation due to inhibition of PTEN facilitates NMD; (iii) insulin stimulation increases the binding of up-frameshift factor 1 (UPF1), most likely to eIF4E-bound PTC-containing transcripts; and (iv) insulin stimulation induces the colocalization of UPF1 and eIF4E in processing bodies. These results illustrate how extracellular signaling promotes the removal of eIF4E-bound NMD targets. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 7 |
| Volume Number | 1859 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-07-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Eukaryotic Initiation Factor-4E Physiology Insulin Pharmacology Nonsense Mediated MRNA Decay Drug Effects Animals HeLa Cells Protein Biosynthesis Genetics Signal Transduction Sirolimus Up-Regulation Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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