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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Gutiérrez-castrellón, Pedro Gómez-manzo, Saúl Marcial-quino, Jaime Enríquez-flores, Sergio De La Mora-de La Mora, Ignacio López-velázquez, Gabriel Vanoye-carlo, América Sierra-palacios, Edgar Navarrete-vázquez, Gabriel García-torres, Itzhel Colín-lozano, Blanca |
| Description | Author Affiliation: García-Torres I ( Laboratorio de Bioquímica-Genética, Instituto Nacional de Pediatría, Secretaría de Salud, 04530 México, D.F., México. Electronic address: itzheltorres@hotmail.com.); de la Mora-de la Mora I ( Laboratorio de Bioquímica-Genética, Instituto Nacional de Pediatría, Secretaría de Salud, 04530 México, D.F., México. Electronic address: ignaciodelamora@yahoo.com.mx.); Marcial-Quino J ( CONACyT Research Fellow-Instituto Nacional de Pediatría, Secretaría de Salud, 04530 México, D.F., México. Electronic address: jmarcialqu@conacyt.mx.); Gómez-Manzo S ( Laboratorio de Bioquímica-Genética, Instituto Nacional de Pediatría, Secretaría de Salud, 04530 México, D.F., México. Electronic address: saulmanzo@ciencias.unam.mx.); Vanoye-Carlo A ( Laboratorio de Neurociencias, Instituto Nacional de Pediatría, Secretaría de Salud, 04530 México, D.F., México. Electronic address: america_vc@yahoo.com.mx.); Navarrete-Vázquez G ( Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, 62209 Cuernavaca, Morelos, México. Electronic address: gabriel_navarrete@uaem.mx.); Colín-Lozano B ( Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, 62209 Cuernavaca, Morelos, México. Electronic address: clbi_ff@uaem.mx.); Gutiérrez-Castrellón P ( Hospital General Dr. Manuel Gea González, México, D.F., México. Electronic address: inpcochrane@gmail.com.); Sierra-Palacios E ( Colegio de Ciencias y Humanidades. Plantel Casa Libertad. Universidad Autónoma de la Ciudad de México, México, D.F., México. Electronic address: edgar.sierra@uacm.edu.com.); López-Velázquez G ( Laboratorio de Bioquímica-Genética, Instituto Nacional de Pediatría, Secretaría de Salud, 04530 México, D.F., México. Electronic address: glv_1999@yahoo.com.); Enríquez-Flores S ( Laboratorio de Bioquímica-Genética, Instituto Nacional de Pediatría, Secretaría de Salud, 04530 México, D.F., México. Electronic address: sergioenriquezflores@gmail.com.) |
| Abstract | Background Proton pump inhibitors (PPIs) are extensively used in clinical practice because of their effectiveness and safety. Omeprazole is one of the best-selling drugs worldwide and, with other PPIs, has been proposed to be potential drugs for the treatment of several diseases. We demonstrated that omeprazole shows cytotoxic effects in Giardia and concomitantly inactivates giardial triosephosphate isomerase (GlTIM). Therefore, we evaluated the efficiency of commercially available PPIs to inactivate this enzyme. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Part | Pt A |
| Issue Number | 1 |
| Volume Number | 1860 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Drug Design Giardia Lamblia Drug Effects Proton Pump Inhibitors Pharmacology Triose-Phosphate Isomerase Antagonists & Inhibitors Enzyme Stability Enzymology Hydrophobic And Hydrophilic Interactions Mass Spectrometry Chemistry Physiology Research Support, Non-U.S. Gov't Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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