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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Killick, Mark Capovilla, Alexio Papathanasopoulos, Maria Moolla, Naazneen |
| Description | Author Affiliation: Moolla N ( HIV Pathogenesis Research Unit, Department of Molecular Medicine and Haematology, University of the Witwatersrand, Faculty of Health Sciences, 7 York Road Parktown, 2193 Johannesburg, South Africa.); Killick M ( HIV Pathogenesis Research Unit, Department of Molecular Medicine and Haematology, University of the Witwatersrand, Faculty of Health Sciences, 7 York Road Parktown, 2193 Johannesburg, South Africa.); Papathanasopoulos M ( HIV Pathogenesis Research Unit, Department of Molecular Medicine and Haematology, University of the Witwatersrand, Faculty of Health Sciences, 7 York Road Parktown, 2193 Johannesburg, South Africa.); Capovilla A ( HIV Pathogenesis Research Unit, Department of Molecular Medicine and Haematology, University of the Witwatersrand, Faculty of Health Sciences, 7 York Road Parktown, 2193 Johannesburg, South Africa. Electronic address: alexio.capovilla@gmail.com.) |
| Abstract | Background CD4 is a glycoprotein expressed on the surfaces of certain immune cells. On lymphocytes, an important function of CD4 is to co-engage Major Histocompatibility Complex (MHC) molecules with the T Cell Receptor (TCR), a process that is essential for antigen-specific activation of T cells. CD4 localizes dynamically into distinct membrane microdomains, an important feature of its immunoregulatory function that has also been shown to influence the efficiency of HIV replication. However, the mechanism by which CD4 localization is regulated and the biological significance of this is incompletely understood. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 9 |
| Volume Number | 1860 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-09-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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