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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Melnik, Tatiana N. Glukhov, Anatoly S. Uversky, Vladimir N. Melnik, Bogdan S. Nagibina, Galina S. |
| Description | Author Affiliation: Melnik BS ( Institute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Moscow, Region, Russia. Electronic address: bmelnik@phys.protres.ru.); Nagibina GS ( Institute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Moscow, Region, Russia.); Glukhov AS ( Institute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Moscow, Region, Russia.); Melnik TN ( Institute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Moscow, Region, Russia.); Uversky VN ( Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia) |
| Abstract | Various effects of amino acid substitutions on properties of globular proteins have been described in a large number of research papers. Nevertheless, no definite “rule” has been formulated as of yet that could be used by experimentalists to introduce desirable changes in the properties of proteins. Herein we attempt to establish such a “rule”. To this end, a hypothesis is proposed on the effects of substitutions of hydrophobic residues with large number of contacts on free energies of different states of a globular protein. The hypothesis states: Substitutions of hydrophobic residues engaged in a large number of residue-residue contacts would not change the folding rate of a protein but could affect its unfolding rate. This hypothesis was verified by both theoretical and experimental analyses, generating a general rule that can facilitate the work of experimentalists on constructing mutant forms of proteins. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 12 |
| Volume Number | 1864 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-12-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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