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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pluta, Krystian Suwinska, Kinga Shkurenko, Aleksander Morak-mlodawska, Beata Jelen, Malgorzata |
| Description | Author Affiliation: Jelen M ( Department of Organic Chemistry, The Medical University of Silesia, ul. Jagiellonska 4, PL-41 200 Sosnowiec, Poland.) |
| Abstract | In the title molecule {systematic name: N-[3-(diquino[3,2-b;2′,3′-e][1,4]thiazin-6-yl)propyl]-4-methylbenzenesulfonamide}, $C_{28}H_{24}N_{4}O_{2}S_{2},$ the pentacyclic system is relatively planar [maximum deviation from the mean plane = 0.242 (1) Å]. The dihedral angle between two quinoline ring systems is 8.23 (2)° and that between the two halves of the 1,4-thiazine ring is 5.68 (3)°. The conformation adopted by the 3-(p-tolylsulfonylamino)propyl substituent allows for the formation of an intramolecular N—H⋯N hydrogen bond and places the benzene ring of this substituent above one of the quinoline fragments of the pentacyclic system. In the crystal, molecules are arranged via π–π stacking interactions into (0-11) layers [centroid–centroid distances = 3.981 (1)–4.320 (1) Å for the rings in the pentacyclic system and 3.645 (1) Å for the tolyl benzene rings]. In addition, molecules are involved in weak C—H⋯O, which connect the layers, and C—H⋯S hydrogen bonds. The title compound shows promising anticancer activity against renal cancer cell line UO-31. |
| ISSN | 20569890 |
| e-ISSN | 16005368 |
| Journal | Acta Crystallographica Section E Structure Reports Online |
| Issue Number | Pt 6 |
| Volume Number | 69 |
| Language | English |
| Publisher | IUCr/Wiley |
| Publisher Date | 2013-06-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Crystallography |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Condensed Matter Physics Materials Science |
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