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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Huberman, E. Marquardt, H. Heidelberger, C. Grover, P. L. Kuroki, T. Sims, P. |
| Abstract | The K-region epoxides and cis-dihydrodiols derived from benz(a)anthracene and from dibenz(a,h)-anthracene have been found to be more active in the production of malignant transformation in hamster embryo cells than the hydrocarbons or the corresponding K-region phenols. The K-region epoxides derived from benz(a)-anthracene and from 3-methylcholanthrene were also active in transforming a clone of ventral prostate cells from the C3H mouse that was not readily transformed by the parent hydrocarbons. The phenols were the most toxic compounds tested but did not transform cells; this confirms that toxicity and transformation are not directly related events. The results obtained support the view that metabolism of polycyclic hydrocarbons precedes toxicity and transformation in rodent cells in culture. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 6 |
| Volume Number | 68 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1971-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Transformation, Neoplastic Cells, Cultured Drug Effects Polycyclic Compounds Pharmacology Animals Benz(a)Anthracenes Clone Cells Cricetinae Embryo, Mammalian Cytology Ethers, Cyclic Hydrocarbons Methylcholanthrene Mice Nitrosoguanidines Phenols Prostate Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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