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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Baum, S. G. Fox, R. I. |
| Abstract | The DNA and protein components of the adenovirus 7-simian virus (SV)40 hybrid virus 'E46(+)' have been investigated. The Ad.7-SV40 hybrid DNA genome could be distinguished from nonhybrid Ad. 7 genome on the basis of its molecular weight in an alkaline sucrose gradient. The hybrid genome could also be separated from nonhybrid adenovirus 2 DNA when purified transcapsidant adenovirus 2(+t7) (Ad.7-SV40 DNA within an Ad.2 capsid) was studied. The presence and amount of SV40 DNA in the hybrid virus genome was determined by DNA-RNA hybridization. The results presented suggest: (i) that about 10% of the particles in the E46(+) preparations contained SV40 DNA covalently linked to adenovirus DNA; (ii) that the hybrid virus genome has a molecular weight 10-12% lower than that of nonhybrid virus, consistent with a deletion of adenovirus DNA; and (iii) that the hybrid virus contained only 40-50% of a total SV40 genome. The protein components of the Ad.7-SV40 hybrid virus were examined by acrylamide gel electrophoresis in sodium dodecyl sulfate. No significant quantitative or qualitative differences between the proteins of hybrid and nonhybrid adenovirus were demonstrated. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 7 |
| Volume Number | 68 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1971-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Adenoviridae DNA, Viral Simian Virus 40 Viral Proteins Carcinoma Cell Line Centrifugation, Density Gradient Electrophoresis Embryo, Mammalian Escherichia Coli Enzymology Hybridization, Genetic Kidney Molecular Weight Mouth Neoplasms Nucleic Acid Hybridization RNA Nucleotidyltransferases RNA, Messenger Isolation & Purification RNA, Viral Tritium Uridine Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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